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CS-2890 |
| CAS No.: |
210302-17-3 |
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| 備注： |
中文名稱CS-2890中文同義詞化合物BAM15;N5,N6-雙(2-氟苯基)-[1,2,5]惡二唑并[3,4-B]吡嗪-5,6-二胺;BAM15,線粒體質(zhì)子解偶聯(lián)劑;CS-2890BAM15英文名稱BAM15英文同義詞BAM15;N,N’-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine;CS-2890;[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine,N5,N6-bis(2-fluorophenyl)-;BAM15>=98%(HPLC);BAM15(N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine);inhibit,BAM-15,Inhibitor,BAM15,BAM15,MitochondrialMetabolismCAS號(hào)210302-17-3分子式C16H10F2N6O分子量340.29EINECS號(hào)201-118-7相關(guān)類別抑制劑Mol文件210302-17-3.mol結(jié)構(gòu)式CS-2890性質(zhì)沸點(diǎn)421.7±55.0°C(Predicted)密度1.548±0.06g/cm3(Predicted)儲(chǔ)存條件-20°C溶解度溶于DMSO(35mg/ml)形態(tài)粉末酸度系數(shù)(pKa)-2.40±0.50(Predicted)顏色白色至米色穩(wěn)定性從購(gòu)買之日起2年內(nèi)保持穩(wěn)定。DMSO溶液可在-20°C下保存長(zhǎng)達(dá)1個(gè)月。CS-2890用途與合成方法生物活性BAM15是一種新型的mitochondrialprotonophore的解偶聯(lián)劑，能夠保護(hù)哺乳動(dòng)物免受急性腎缺血-再灌注損傷和冷誘導(dǎo)的微管損傷。BAM15也是一種有效的AMPK激活劑。BAM15可減輕iPS分化的視網(wǎng)膜組織中運(yùn)輸引起的凋亡。靶點(diǎn)TargetValueAMPK()體外研究BAM15isabletoincreaseO2consumptionacrossabroaddosinChemicalbookgrangewithoutincreasingROS.BAM15andFCCParestructurallyunrelatedanditisobservedthatlowdosesofBAM15from100nMto1μMincreasecellularO2consumptionrate(OCR)toasimilardegreeasFCCP,buthigherconcentrationsfrom1μMto50μMrevealthatBAM15isabletomaintainuncoupledrespirationatahighrateinarangeofcelllines.BAM15isfullycapableofincreasingmitochondrialrespirationinthepresenceofoligomycinanddoessoacrossabroaderconcentrationrangethanFCCPinbothmyoblastsandhepatocytes.BAM15inducesmitochondrialswelling,demonstratingthatBAM15isaprotonophore.BAM15-treatedcellsaremoreviablethanFCCP-treatedcellswhenadministeredacrossabroaddosingrangeupto50μM.體內(nèi)研究Comparetovehicle-treatedmice,animalsthatreceiveBAM15areprotectedfromkidneyinjuryasindicatedbylowerplasmacreatininelevelsat24and48hpost-ischemia,reducedtubularnecrosis,lessdepletionofbrushbordervilli,lessobstructionofproximaltubules,andlessimmunecellinfiltration. |
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聯(lián)系人： |
金經(jīng)理 |
地 址： |
湖北省武漢市東湖新技術(shù)開發(fā)區(qū)光谷大道03號(hào) |
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430000 |
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18995560451 |
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15102708508 |
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